TRPV4-pathy, a novel channelopathy affecting diverse systems
نویسندگان
چکیده
منابع مشابه
A channelopathy mechanism revealed by direct calmodulin activation of TrpV4.
Ca(2+)-calmodulin (CaM) regulates varieties of ion channels, including Transient Receptor Potential vanilloid subtype 4 (TrpV4). It has previously been proposed that internal Ca(2+) increases TrpV4 activity through Ca(2+)-CaM binding to a C-terminal Ca(2+)-CaM binding domain (CBD). We confirmed this model by directly presenting Ca(2+)-CaM protein to membrane patches excised from TrpV4-expressin...
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TRPV4 ion channel mediates vascular mechanosensitivity and vasodilation. Here, we sought to explore whether non-mechanical activation of TRPV4 could limit vascular inflammation and atherosclerosis. We found that GSK1016790A, a potent and specific small-molecule agonist of TRPV4, induces the phosphorylation and activation of eNOS partially through the AMPK pathway. Moreover, GSK1016790A inhibite...
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ژورنال
عنوان ژورنال: Journal of Human Genetics
سال: 2010
ISSN: 1434-5161,1435-232X
DOI: 10.1038/jhg.2010.37